COPII-coated vesicle cargo loading

Across TCGA cell cohorts, RNA activity of the COPII-coated vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24D, PTCD2, and SELENOI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPII-coated vesicle cargo loading activity versus SEC24D in URINARY_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEC24D →	+0.711	+1.243	.004	<.001	3	5
LUNG_NSCLC_LUSC	PTCD2 →	+0.539	+1.325	<.001	.001	3	4
URINARY_TRACT	SELENOI →	-0.759	-1.903	.007	<.001	3	4
LUNG_NSCLC_LUAD	CEP85L →	+0.364	+0.817	.003	.001	3	4
SKIN	TUSC3 →	+1.359	+0.551	.005	.004	3	4
LUNG_NSCLC_LUSC	CKMT1A →	-2.930	-1.455	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090110 vs SEC24D — URINARY_TRACT

Explore this scatter interactively →