Cochlea morphogenesis

Across TCGA cell cohorts, RNA activity of the Cochlea morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM234B, DYNLL1, and FUS, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cochlea morphogenesis activity versus FAM234B in LUNG_NSCLC_LUAD (Pearson r = -0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM234B →	-0.830	-0.820	<.001	.006	1	1
LUNG_NSCLC_LUAD	DYNLL1 →	+0.135	+0.820	.006	.006	1	1
LUNG_NSCLC_LUAD	FUS →	+0.424	+0.820	.005	.006	1	1
LUNG_NSCLC_LUAD	TNRC6A →	+0.764	+0.820	.008	.006	1	1
LUNG_NSCLC_LUAD	PHGDH →	+5.090	+0.820	<.001	.006	1	1
LUNG_NSCLC_LUAD	FAM76A →	-0.470	-0.820	.003	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090103 vs FAM234B — LUNG_NSCLC_LUAD

Explore this scatter interactively →