Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

pathway activity — cross-omics
GO:0090101Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSC5D, KANK2, and SERBP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus SSC5D in BRCA (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASSC5D →+0.763+0.030<.001<.001310
UCECKANK2 →+0.698+0.047<.001<.001310
OVSERBP1 →-0.259-0.034<.001<.00139
GBMSERPING1 →+0.669+0.040<.001<.00139
OVSNX18 →+0.473+0.028.005<.00139
UCECTAGLN →+0.882+0.050<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090101 vs SSC5D — BRCA

Per-sample scatter of Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity vs SSC5D in BRCA.

Explore this scatter interactively →

Exploration