Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHB1, CEP95, and TAF4B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus EPHB1 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EPHB1 →	+0.666	+0.178	.001	<.001	3	4
BRCA	CEP95 →	+0.487	+0.177	.008	.007	3	4
CCRCC	TAF4B →	+0.294	+0.188	<.001	.003	3	4
PDAC	LMBR1L →	+0.314	+0.162	<.001	.005	3	3
PDAC	CRABP2 →	+0.945	+0.163	.001	<.001	3	3
PDAC	FCRLB →	+0.318	+0.185	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090101 vs EPHB1 — UCEC

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