Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS3, LMCD1, and HSPA12B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus SORBS3 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SORBS3 →	+0.592	+0.055	<.001	.001	3	9
OV	LMCD1 →	+0.536	+0.036	<.001	<.001	3	9
BRCA	HSPA12B →	+0.589	+0.036	<.001	<.001	3	9
UCEC	JCAD_S770 →	+0.757	+0.058	.003	<.001	3	9
UCEC	SEPTIN4_S432 →	+0.529	+0.051	.005	.001	3	8
COAD	EIF3G →	-0.164	-0.036	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090100 vs SORBS3 — UCEC

Explore this scatter interactively →