Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLEC3B, EFEMP1, and FBLN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus CLEC3B in BRCA (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC3B →	+0.642	+0.036	<.001	<.001	3	10
OV	EFEMP1 →	+1.001	+0.043	<.001	<.001	3	10
OV	FBLN1 →	+0.823	+0.039	<.001	<.001	3	10
COAD	LMCD1 →	+0.663	+0.036	<.001	<.001	3	10
CCRCC	LTBP2 →	+0.702	+0.021	<.001	<.001	3	10
BRCA	LUM →	+0.936	+0.033	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090092 vs CLEC3B — BRCA

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