Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZDHHC15, PKD2, and HAP1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus ZDHHC15 in COAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZDHHC15 →	+0.264	+0.171	<.001	.001	3	2
COAD	PKD2 →	+0.617	+0.179	.007	.001	3	2
BRCA	HAP1 →	+0.385	+0.198	<.001	.002	3	2
COAD	PRR16 →	+0.419	+0.159	.002	<.001	3	2
COAD	NUDT9P1 →	+0.492	+0.218	<.001	<.001	3	2
COAD	MIR100HG →	+0.660	+0.197	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090092 vs ZDHHC15 — COAD

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