Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GORASP2_S451, GTF2F1_T389, and KIDINS220_S1521, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus GORASP2_S451 in OV (Pearson r = -0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GORASP2_S451 →	-1.141	-0.536	<.001	.003	3	2
OV	GTF2F1_T389 →	-1.373	-0.339	<.001	<.001	3	2
OV	KIDINS220_S1521 →	-1.980	-0.367	<.001	.001	3	2
COAD	REM1_S18 →	+0.431	+0.178	<.001	<.001	3	1
BRCA	RILPL1_S346 →	+0.526	+0.260	.001	.002	2	2
COAD	RIOK2_S337 →	-0.296	-0.161	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090092 vs GORASP2_S451 — OV

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