Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, LSM7, and BAZ1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway activity versus CSNK1G2 in LUNG_SCLC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CSNK1G2 →	+0.437	+0.155	.007	.007	3	6
PANCREAS	LSM7 →	+0.736	+0.187	.006	.002	3	6
BLOOD_Leukemia	BAZ1B →	+0.659	+0.143	.002	.005	3	5
BLOOD_Leukemia	DUSP3 →	-1.721	-0.186	<.001	<.001	3	5
LUNG_SCLC	AUP1 →	-0.348	-0.131	.001	.008	3	5
LUNG_SCLC	CLU →	-2.786	-0.184	.007	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090092 vs CSNK1G2 — LUNG_SCLC

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