Negative regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL24, ATP5F1B, and RPL9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of canonical Wnt signaling pathway activity versus MRPL24 in OESOPHAGUS (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MRPL24 →	-0.821	-0.233	<.001	.003	3	7
UPPER_AERODIGESTIVE_TRACT	ATP5F1B →	-0.753	-0.194	.005	.001	3	6
LARGE_INTESTINE	RPL9 →	-0.597	-0.193	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	RPLP0 →	-1.114	-0.216	.003	.006	2	6
BLOOD_Leukemia	IRF1 →	+1.180	+0.372	.002	.008	3	5
BLOOD_Lymphoma	WDFY1 →	-1.033	-0.242	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090090 vs MRPL24 — OESOPHAGUS

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