Foam cell differentiation

Across TCGA patient cohorts, RNA activity of the Foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCP2, MIR3945HG, and CDC42BPA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Foam cell differentiation activity versus LCP2 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LCP2 →	+0.756	+0.318	<.001	<.001	3	7
HNSC	MIR3945HG →	+0.742	+0.186	<.001	<.001	3	7
HNSC	CDC42BPA →	-0.660	-0.200	.001	<.001	3	6
GBM	LILRB2 →	+0.904	+0.255	<.001	.001	3	6
GBM	KLHL6 →	+0.642	+0.289	.008	.001	3	6
UCEC	TOMM20 →	-0.559	-0.187	.008	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090077 vs LCP2 — LSCC

Explore this scatter interactively →