Foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC15, SH3RF1, and NEMP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC15 grouped by Foam cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC15 →	-0.560	-1.151	.009	<.001	3	4
LARGE_INTESTINE	SH3RF1 →	-1.051	-1.445	.002	<.001	3	4
LARGE_INTESTINE	NEMP2 →	-1.156	-1.038	.001	.006	3	4
LIVER	PLTP →	+3.803	+1.365	.008	.004	3	4
LIVER	ALKBH2 →	-0.712	-1.313	.005	.008	3	4
LUNG_SCLC	RPL22 →	-1.022	-1.609	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC15 by Foam cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →