Foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Foam cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCZ, PRDM16, and ADCY9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCZ grouped by Foam cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRKCZ →	-0.139	-0.213	.002	.007	3	5
LARGE_INTESTINE	PRDM16 →	+0.147	+0.235	<.001	<.001	3	4
STOMACH	ADCY9 →	-0.219	-0.359	.006	<.001	3	4
BLOOD_Myeloma	DMRT3 →	-0.338	-0.172	.003	.009	3	4
LUNG_NSCLC_LUSC	TFPI →	-0.206	-0.187	.001	.004	3	4
BREAST	SMARCE1 →	-0.330	-0.339	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCZ by Foam cell differentiation activity — BREAST

Explore this box plot interactively →