Foam cell differentiation

Across TCGA cell cohorts, RNA activity of the Foam cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF40B, FZD6, and YKT6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Foam cell differentiation activity versus PRPF40B in LIVER (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PRPF40B →	-1.169	-0.486	.003	.004	3	7
SOFT_TISSUE	FZD6 →	-2.623	-1.041	.002	.007	3	4
BONE	YKT6 →	-0.855	-1.129	.005	.009	3	4
LARGE_INTESTINE	NUSAP1 →	+0.766	+0.248	.008	.006	3	4
LUNG_SCLC	CCDC62 →	+0.336	+1.529	.001	<.001	3	4
LUNG_SCLC	DHX9 →	+0.699	+1.408	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090077 vs PRPF40B — LIVER

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