Negative regulation of ribosome biogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of ribosome biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A10, GGA2, and NUP210, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ribosome biogenesis activity versus SLC16A10 in STOMACH (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC16A10 →	+1.548	+1.047	.004	.004	3	5
KIDNEY	GGA2 →	+1.409	+0.298	.009	.003	3	3
KIDNEY	NUP210 →	+2.766	+0.298	.001	.003	3	3
SKIN	PRSS8 →	+0.117	+0.667	.006	.009	3	3
STOMACH	METTL22 →	+1.343	+1.541	.005	<.001	3	3
SKIN	KIZ →	+0.839	+0.642	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090071 vs SLC16A10 — STOMACH

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