Regulation of ribosome biogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of ribosome biogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS6, LPP, and HABP4_S108, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ribosome biogenesis activity versus RPS6 in COAD (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS6 →	-0.209	-0.042	.001	.001	3	6
COAD	LPP →	+0.380	+0.024	.001	.003	3	6
UCEC	HABP4_S108 →	+0.373	+0.051	<.001	.002	3	5
PDAC	SORBS3 →	+0.423	+0.054	<.001	<.001	3	5
CCRCC	TGFB1I1 →	+0.415	+0.032	<.001	.001	3	5
COAD	TNS1 →	+0.528	+0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090069 vs RPS6 — COAD

Explore this scatter interactively →