Regulation of ribosome biogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of ribosome biogenesis pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Regulation of ribosome biogenesis pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and HNSC, show the opposite pattern, with higher activity associated with better survival.

SCLC, LGG, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.462	0.767	<.001	102	view →
LGG	OS	Median	All	0.742	0.865	<.001	49	view →
LUAD	DFS	Median	III,IV	0.596	0.281	.007	39	view →
HNSC	DFS	Quartile	III,IV	0.547	0.332	.004	31	view →
KIRC	DFS	Quartile	IV	0.357	0.758	.003	28	view →
KICH	OS	Median	All	0.872	1.000	.008	26	view →
SKCM	OS	Median	All	0.391	0.286	.013	16	view →
LIHC	DFS	Median	All	0.482	0.613	.010	16	view →
LUSC	OS	Tertile	III,IV	0.248	0.774	.020	14	view →
ESCA	OS	Tertile	III,IV	0.701	0.323	.015	14	view →
BRCA	OS	Quartile	II,III,IV	0.507	0.714	.014	13	view →
THCA	OS	Tertile	All	0.956	1.000	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0090069–SCLC (DFS)

Open the SCLC breakdown →