Regulation of ribosome biogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of ribosome biogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHTKD1, SLC5A6, and COPZ2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHTKD1 grouped by Regulation of ribosome biogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DHTKD1 →	+1.210	+1.378	<.001	.002	3	5
BLOOD_Leukemia	SLC5A6 →	+1.000	+1.310	<.001	.001	3	5
SOFT_TISSUE	COPZ2 →	-3.614	-1.771	.002	<.001	3	4
OESOPHAGUS	PHOSPHO2 →	+0.663	+1.422	.003	.001	3	4
LUNG_NSCLC_LUSC	BST2 →	-4.603	-1.472	.002	.004	3	4
CNS	TGFB1 →	-0.973	-0.985	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHTKD1 by Regulation of ribosome biogenesis activity — STOMACH

Explore this box plot interactively →