Negative regulation of cell migration involved in sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP1, LUM, and TBC1D2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell migration involved in sprouting angiogenesis activity versus EFEMP1 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EFEMP1 →	+0.718	+0.048	<.001	.001	3	7
OV	LUM →	+0.865	+0.058	<.001	<.001	3	7
LSCC	TBC1D2B →	+0.311	+0.055	<.001	<.001	3	7
OV	SNX9 →	+0.449	+0.050	<.001	.001	3	6
LSCC	TLN1 →	+0.268	+0.062	<.001	<.001	3	6
LSCC	U2SURP →	-0.204	-0.047	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090051 vs EFEMP1 — OV

Explore this scatter interactively →