Negative regulation of cell migration involved in sprouting angiogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of cell migration involved in sprouting angiogenesis pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 36 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Negative regulation of cell migration involved in sprouting angiogenesis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as THCA and UCEC, show the opposite pattern, with higher activity associated with better survival.

UVM, THCA, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.272	0.836	.010	55	view →
THCA	DFS	Tertile	IV	0.856	0.438	.001	55	view →
UCEC	DFS	Median	III,IV	0.664	0.476	.020	44	view →
KIRP	DFS	Quartile	All	0.655	0.867	.010	35	view →
KIRC	DFS	Median	III,IV	0.588	0.386	.007	20	view →
COAD	DFS	Tertile	III,IV	0.530	0.752	.014	19	view →
READ	DFS	Median	II,III,IV	0.672	0.355	.007	18	view →
STAD	OS	Quartile	All	0.599	0.845	.012	15	view →
OV	OS	Tertile	IV	0.232	0.454	.013	14	view →
THYM	OS	Median	II,III,IV	0.883	1.000	.009	11	view →
LUSC	OS	Median	III,IV	0.227	0.450	.021	10	view →
SCLC	DFS	Quartile	All	0.865	0.538	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0090051–UVM (OS)

Open the UVM breakdown →