Negative regulation of cell migration involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell migration involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM71A, RHOC, and MIF4GD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell migration involved in sprouting angiogenesis activity versus FAM71A in LARGE_INTESTINE (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71A →	-0.047	-0.406	.009	.002	3	4
STOMACH	RHOC →	-1.145	-0.309	.005	.007	3	4
LUNG_NSCLC_LUAD	MIF4GD →	+0.652	+0.413	.004	.007	3	4
BLOOD_Lymphoma	ARHGDIB →	+4.384	+0.355	<.001	<.001	3	4
BLOOD_Lymphoma	RTN4IP1 →	+0.986	+0.268	.007	.002	3	4
BLOOD_Lymphoma	TPCN1 →	+1.560	+0.318	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090051 vs FAM71A — LARGE_INTESTINE

Explore this scatter interactively →