Regulation of protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Regulation of protein kinase C signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LYN, ATL1, and ROCK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein kinase C signaling activity versus LYN in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LYN →	-0.420	-0.034	<.001	<.001	3	6
LUAD	ATL1 →	+0.429	+0.048	<.001	<.001	3	5
LSCC	ROCK2 →	+0.151	+0.048	.008	<.001	3	5
BRCA	SPARCL1_S92 →	+0.773	+0.030	<.001	<.001	3	5
LSCC	MAP1A_S644 →	+0.587	+0.038	<.001	<.001	3	5
BRCA	RPL11 →	-0.177	-0.031	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090036 vs LYN — BRCA

Explore this scatter interactively →