Regulation of protein kinase C signaling

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of protein kinase C signaling pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Regulation of protein kinase C signaling pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LIHC and HNSC, show the opposite pattern, with higher activity associated with better survival.

CESC, ESCA, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.615	0.830	<.001	52	view →
ESCA	OS	Median	All	0.577	0.787	<.001	42	view →
UVM	OS	Quartile	All	0.248	0.853	<.001	40	view →
OV	DFS	Tertile	IV	0.297	0.588	.001	38	view →
KIRC	DFS	Median	IV	0.520	0.702	.005	36	view →
LIHC	OS	Median	II,III,IV	0.590	0.328	<.001	35	view →
LUAD	DFS	Median	II,III,IV	0.454	0.606	.012	30	view →
ACC	DFS	Median	All	0.465	0.736	.015	26	view →
SKCM	DFS	Quartile	All	0.529	0.774	.001	25	view →
COAD	DFS	Tertile	All	0.706	0.810	.009	23	view →
KIRP	OS	Median	III,IV	0.139	0.661	.010	19	view →
HNSC	OS	Median	IV	0.639	0.355	.003	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0090036–CESC (DFS)

Open the CESC breakdown →