Regulation of protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Regulation of protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP12, ASPA, and AOX1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein kinase C signaling activity versus AKAP12 in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKAP12 →	+1.180	+1.149	<.001	<.001	3	10
BRCA	ASPA →	+0.563	+0.821	<.001	<.001	3	9
HNSC	AOX1 →	+1.185	+0.680	<.001	.003	3	9
COAD	MGP →	+1.606	+0.794	<.001	<.001	3	8
COAD	GYPC →	+0.646	+0.840	.001	.001	3	8
HNSC	ABCA8 →	+1.081	+0.697	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090036 vs AKAP12 — LUAD

Explore this scatter interactively →