Regulation of protein kinase C signaling

Across TCGA cell cohorts, RNA activity of the Regulation of protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf116, CRB3, and FAM102A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf116 grouped by Regulation of protein kinase C signaling-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C1orf116 →	+2.518	+1.298	<.001	<.001	3	5
LUNG_NSCLC_LUAD	CRB3 →	+1.556	+0.692	.001	.002	3	4
LUNG_NSCLC_LUAD	FAM102A →	+1.081	+0.931	.001	<.001	3	4
URINARY_TRACT	RAB11FIP1 →	+2.244	+1.698	<.001	<.001	3	4
URINARY_TRACT	FOXD1 →	-3.939	-2.272	.003	<.001	3	4
BREAST	HLA-DQB1 →	+1.677	+1.020	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf116 by Regulation of protein kinase C signaling activity — BREAST

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