Regulation of protein kinase C signaling

Across TCGA cell cohorts, RNA activity of the Regulation of protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB1, EGFR, and CRIM1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein kinase C signaling activity versus HSPB1 in URINARY_TRACT (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HSPB1 →	+2.142	+0.362	.005	<.001	2	10
OESOPHAGUS	EGFR →	+3.030	+0.340	<.001	.004	2	6
LUNG_NSCLC_LUAD	CRIM1 →	+1.736	+0.237	<.001	.002	2	6
LIVER	BCL9L →	+1.282	+0.299	.004	.005	3	5
LARGE_INTESTINE	TFF3 →	-4.547	-0.338	.004	.002	3	5
LIVER	MYOF →	+3.017	+0.260	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090036 vs HSPB1 — URINARY_TRACT

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