Negative regulation of monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative regulation of monocyte chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMC1, NXPE3, and STX1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMC1 grouped by Negative regulation of monocyte chemotaxis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMC1 →	+0.445	+1.191	.003	.009	2	5
BLOOD_Leukemia	NXPE3 →	-0.178	-1.293	.001	.001	3	4
OESOPHAGUS	STX1B →	-0.200	-0.334	.008	.004	2	4
OVARY	BIRC2 →	-0.161	-0.300	.005	.006	3	3
BLOOD_Myeloma	COL1A2 →	+0.271	+1.904	.005	<.001	3	3
LIVER	ASCL2 →	-0.251	-0.242	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMC1 by Negative regulation of monocyte chemotaxis activity — LUNG_SCLC

Explore this box plot interactively →