Regulation of monocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, NCF4, and SAMSN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monocyte chemotaxis activity versus CYTH4 in GBM (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+0.857	+0.153	<.001	<.001	3	10
GBM	NCF4 →	+0.832	+0.138	<.001	<.001	3	8
GBM	SAMSN1 →	+0.743	+0.125	<.001	<.001	3	8
BRCA	NCF1C →	+0.626	+0.187	<.001	<.001	3	8
GBM	LAIR1 →	+0.869	+0.157	<.001	<.001	3	8
GBM	FCGR2B →	+1.225	+0.161	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090025 vs CYTH4 — GBM

Explore this scatter interactively →