Regulation of monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP1, MEX3A, and NINJ1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monocyte chemotaxis activity versus DUSP1 in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DUSP1 →	+3.074	+0.236	<.001	<.001	3	14
BONE	MEX3A →	-2.587	-0.179	<.001	<.001	3	11
BLOOD_Lymphoma	NINJ1 →	+1.469	+0.122	<.001	<.001	3	11
BONE	DRAM1 →	+2.994	+0.287	<.001	<.001	3	10
BONE	B4GALT1 →	+1.827	+0.213	<.001	<.001	3	10
BONE	ZFP36 →	+1.652	+0.224	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090025 vs DUSP1 — LIVER

Explore this scatter interactively →