Regulation of monocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of monocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BDNF, UBTD1, and LGALS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monocyte chemotaxis activity versus BDNF in LUNG_NSCLC_LUAD (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BDNF →	-0.943	-0.385	.007	.007	3	7
BONE	UBTD1 →	-1.833	-0.895	.001	.009	3	6
BLOOD_Lymphoma	LGALS1 →	-6.039	-0.221	<.001	.002	3	6
LUNG_NSCLC_LUAD	S100A14 →	+5.105	+0.505	<.001	.001	3	6
LUNG_SCLC	EVL →	+2.442	+0.311	.001	<.001	3	5
LUNG_SCLC	CLDN9 →	+1.817	+0.311	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090025 vs BDNF — LUNG_NSCLC_LUAD

Explore this scatter interactively →