Regulation of heart rate by cardiac conduction

Across TCGA patient cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PERP, DSG1, and DSC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate by cardiac conduction activity versus PERP in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PERP →	+1.031	+0.679	<.001	<.001	3	5
HNSC	DSG1 →	+1.816	+0.970	.002	<.001	3	4
BRCA	DSC1 →	+0.287	+0.731	.001	.002	3	4
LSCC	TSLP →	+0.463	+0.508	.001	.001	3	4
BRCA	DSG2 →	+0.902	+0.988	<.001	<.001	3	4
LSCC	DSP →	+1.485	+0.878	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086091 vs PERP — LSCC

Explore this scatter interactively →