Regulation of heart rate by cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACIR, IKZF5, and EIF4E3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MACIR grouped by Regulation of heart rate by cardiac conduction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MACIR →	+1.126	+1.065	.008	.002	2	6
PANCREAS	IKZF5 →	+0.483	+0.541	.008	.007	3	4
BREAST	EIF4E3 →	+1.041	+0.639	.002	.006	3	3
PANCREAS	KDM4C →	+0.699	+0.815	.003	.003	3	3
BREAST	KDM5B →	+1.024	+0.779	.001	.001	2	4
PANCREAS	CBR4 →	+1.024	+0.865	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MACIR by Regulation of heart rate by cardiac conduction activity — STOMACH

Explore this box plot interactively →