Regulation of heart rate by cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBX, PRPF18, and ITGA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBX grouped by Regulation of heart rate by cardiac conduction-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BBX →	+0.169	+0.139	<.001	.001	3	5
LUNG_NSCLC_LUAD	PRPF18 →	+0.259	+0.119	.008	.005	3	5
STOMACH	ITGA1 →	-0.255	-0.285	.007	.002	3	5
BONE	TTLL4 →	-0.371	-0.110	.002	.003	3	5
BONE	ITGAV →	-0.779	-0.106	.009	.004	2	5
CNS	GRIPAP1 →	+0.480	+0.086	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBX by Regulation of heart rate by cardiac conduction activity — LUNG_SCLC

Explore this box plot interactively →