Regulation of heart rate by cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF6, GALNT3, and GJB5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate by cardiac conduction activity versus IRF6 in URINARY_TRACT (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IRF6 →	+5.641	+0.632	<.001	<.001	3	8
URINARY_TRACT	GALNT3 →	+3.238	+0.480	<.001	<.001	3	7
URINARY_TRACT	GJB5 →	+4.293	+0.437	<.001	.002	3	7
URINARY_TRACT	ALS2CL →	+3.174	+0.640	.001	<.001	3	7
OESOPHAGUS	CBLC →	+2.484	+0.447	.002	.001	3	7
URINARY_TRACT	EPHA1 →	+4.257	+0.628	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086091 vs IRF6 — URINARY_TRACT

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