Regulation of heart rate by cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of heart rate by cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PKP2, DSP, and JUP, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of heart rate by cardiac conduction activity versus PKP2 in URINARY_TRACT (Pearson r = 0.85).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PKP2 →	+3.157	+0.561	.004	.005	3	15
URINARY_TRACT	DSP →	+2.804	+0.581	<.001	<.001	3	15
SKIN	JUP →	+3.878	+0.758	<.001	.002	3	13
URINARY_TRACT	DSG2 →	+2.584	+0.581	<.001	<.001	3	12
URINARY_TRACT	ATP2B2 →	+2.190	+0.539	.004	.002	3	9
URINARY_TRACT	CTNND1 →	+2.102	+0.753	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086091 vs PKP2 — URINARY_TRACT

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