SA node cell to atrial cardiac muscle cell communication

Across TCGA patient cohorts, RNA activity of the SA node cell to atrial cardiac muscle cell communication pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2_S159, SESTD1, and TLN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SA node cell to atrial cardiac muscle cell communication activity versus FERMT2_S159 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FERMT2_S159 →	+1.041	+0.054	.002	.001	3	7
COAD	SESTD1 →	+0.502	+0.047	.008	.004	3	7
COAD	TLN2 →	+0.226	+0.036	<.001	<.001	3	7
COAD	VCAN →	+0.870	+0.059	<.001	<.001	3	7
COAD	DPYSL2 →	+0.368	+0.040	<.001	.002	3	7
GBM	PLCB1 →	+0.707	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086070 vs FERMT2_S159 — OV

Explore this scatter interactively →