SA node cell to atrial cardiac muscle cell communication

Across TCGA pan-cancer cohorts, RNA activity of the SA node cell to atrial cardiac muscle cell communication pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and LUSC, show the opposite pattern, with lower activity in tumor tissue.

BLCA, LIHC, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	All	III,IV	−0.102	<.001	10	view →
LIHC	All	All	+0.067	<.001	9	view →
LUSC	Male	All	−0.090	<.001	8	view →
THCA	All	II,III,IV	−0.045	<.001	8	view →
LUAD	Female	III,IV	−0.108	<.001	7	view →
UCEC	All	All	−0.090	<.001	6	view →
BRCA	All	All	−0.033	<.001	4	view →
CHOL	All	All	+0.073	.001	2	view →
HNSC	Female	III,IV	+0.066	.005	2	view →
KIRP	All	All	−0.030	.010	2	view →
ESCA	Female	All	−0.113	.022	1	view →
READ	Female	All	−0.076	.032	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0086070–BLCA

Open the BLCA breakdown →