SA node cell to atrial cardiac muscle cell communication

Across TCGA patient cohorts, RNA activity of the SA node cell to atrial cardiac muscle cell communication pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK2, CHRDL1, and CCL19, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SA node cell to atrial cardiac muscle cell communication activity versus ANK2 in UCEC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANK2 →	+1.131	+0.480	<.001	<.001	3	8
UCEC	CHRDL1 →	+1.261	+0.474	.006	<.001	3	6
PDAC	CCL19 →	+1.449	+0.428	<.001	.001	3	6
PDAC	PGK1 →	-0.667	-0.558	<.001	<.001	3	6
LUAD	C7 →	+1.470	+0.680	<.001	<.001	3	6
PDAC	NMD3 →	-0.353	-0.536	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086070 vs ANK2 — UCEC

Explore this scatter interactively →