AV node cell to bundle of His cell communication

Across TCGA patient cohorts, RNA activity of the AV node cell to bundle of His cell communication pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2, LARP4, and SEPTIN11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AV node cell to bundle of His cell communication activity versus TNS2 in COAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TNS2 →	+0.340	+0.050	<.001	<.001	3	8
COAD	LARP4 →	-0.218	-0.031	.003	.003	3	8
UCEC	SEPTIN11 →	+0.442	+0.083	<.001	<.001	3	7
COAD	SOD3 →	+0.727	+0.043	<.001	<.001	3	7
UCEC	SORBS3 →	+0.552	+0.077	<.001	<.001	3	7
CCRCC	SYNPO →	+0.471	+0.118	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086067 vs TNS2 — COAD

Explore this scatter interactively →