AV node cell to bundle of His cell communication

Across TCGA patient cohorts, RNA activity of the AV node cell to bundle of His cell communication pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXADR, CACYBPP3, and SNPH, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AV node cell to bundle of His cell communication activity versus CXADR in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CXADR →	+0.756	+0.446	<.001	.001	3	3
HNSC	CACYBPP3 →	-0.860	-0.525	.004	.002	3	3
GBM	SNPH →	+0.824	+0.478	<.001	.006	3	3
GBM	CRYM →	+1.267	+0.430	<.001	<.001	3	3
GBM	MAL2 →	+0.652	+0.499	.003	.002	3	3
GBM	PIN1P1 →	+0.568	+0.434	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086067 vs CXADR — HNSC

Explore this scatter interactively →