AV node cell to bundle of His cell communication

Across TCGA cell cohorts, RNA activity of the AV node cell to bundle of His cell communication pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK7, PRDM12, and COX6A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK7 grouped by AV node cell to bundle of His cell communication-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NEK7 →	+1.083	+1.160	.005	.004	2	6
LIVER	PRDM12 →	-0.100	-1.269	<.001	<.001	3	4
BONE	COX6A1 →	-0.740	-1.562	.001	.003	3	4
BONE	C8orf58 →	+1.200	+2.033	.003	<.001	3	4
LUNG_NSCLC_LUAD	GDF6 →	+0.339	+0.919	<.001	<.001	3	4
LIVER	RBM27 →	+0.618	+1.321	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK7 by AV node cell to bundle of His cell communication activity — PANCREAS

Explore this box plot interactively →