Cell communication involved in cardiac conduction

Across TCGA cell cohorts, RNA activity of the Cell communication involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD13, GNPDA2, and CTSL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAMD13 grouped by Cell communication involved in cardiac conduction-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SAMD13 →	+1.287	+1.099	<.001	.001	3	4
BLOOD_Leukemia	GNPDA2 →	+0.899	+1.176	.001	<.001	3	4
PANCREAS	CTSL →	-1.220	-0.912	<.001	.008	3	4
BLOOD_Lymphoma	ATF4 →	+0.721	+1.874	.005	<.001	3	4
SKIN	XYLT2 →	+0.355	+0.889	.009	.005	3	4
LARGE_INTESTINE	SERPINE2 →	-2.599	-0.953	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAMD13 by Cell communication involved in cardiac conduction activity — PANCREAS

Explore this box plot interactively →