Membrane depolarization during AV node cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during AV node cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHANK3_S1570, SORBS2, and SORBS2_S245, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during AV node cell action potential activity versus SHANK3_S1570 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHANK3_S1570 →	+0.565	+0.149	<.001	<.001	3	6
CCRCC	SORBS2 →	+0.544	+0.077	<.001	<.001	3	6
LSCC	SORBS2_S245 →	+0.527	+0.044	<.001	.002	3	5
GBM	SYNPO_S833 →	+0.656	+0.089	.002	<.001	3	5
CCRCC	CD34 →	+0.586	+0.081	<.001	<.001	3	5
UCEC	CNRIP1 →	+0.593	+0.102	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086045 vs SHANK3_S1570 — UCEC

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