Membrane depolarization during AV node cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during AV node cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR25, RNASEH2A, and NPIPB9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during AV node cell action potential activity versus MIR25 in BRCA (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR25 →	-2.560	-0.313	.002	<.001	3	4
UCEC	RNASEH2A →	-0.214	-0.387	<.001	<.001	3	3
UCEC	NPIPB9 →	-0.215	-0.271	.003	.008	3	3
UCEC	RPL27P7 →	-0.552	-0.370	.005	.001	3	3
UCEC	HMGN2P2 →	-0.790	-0.382	<.001	<.001	3	3
PDAC	RPL21P7 →	-0.327	-0.334	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086045 vs MIR25 — BRCA

Explore this scatter interactively →