Cardiac muscle cell-cardiac muscle cell adhesion

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell-cardiac muscle cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSG2, DSC2, and DSP, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell-cardiac muscle cell adhesion activity versus DSG2 in BRCA (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSG2 →	+0.578	+0.124	<.001	<.001	3	10
BRCA	DSC2 →	+0.996	+0.119	<.001	<.001	3	8
LUAD	DSP →	+0.843	+0.124	<.001	<.001	3	8
LUAD	PKP2 →	+1.039	+0.098	<.001	.002	3	8
GBM	DSG2_S703 →	+0.862	+0.112	.001	<.001	3	7
BRCA	DSP_S22 →	+0.909	+0.102	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086042 vs DSG2 — BRCA

Explore this scatter interactively →