Cardiac muscle cell-cardiac muscle cell adhesion

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell-cardiac muscle cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, BTK, and PERP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell-cardiac muscle cell adhesion activity versus DSP in CCRCC (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DSP →	+1.651	+0.882	<.001	<.001	3	8
HNSC	BTK →	-0.914	-0.960	<.001	.002	3	7
LSCC	PERP →	+1.257	+0.725	<.001	<.001	3	7
HNSC	LAIR1 →	-0.956	-1.054	<.001	.001	3	7
UCEC	GMFG →	-0.945	-0.259	.002	.007	3	7
LSCC	ESRP1 →	+0.996	+0.853	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086042 vs DSP — CCRCC

Explore this scatter interactively →