AV node cell to bundle of His cell signaling

Across TCGA patient cohorts, RNA activity of the AV node cell to bundle of His cell signaling pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2, STXBP1, and THSD7A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AV node cell to bundle of His cell signaling activity versus TNS2 in CCRCC (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNS2 →	+0.364	+0.080	<.001	<.001	3	7
UCEC	STXBP1 →	+0.805	+0.095	<.001	<.001	3	7
PDAC	THSD7A →	+0.496	+0.088	<.001	<.001	3	7
PDAC	TMOD2 →	+0.363	+0.065	<.001	<.001	3	7
LSCC	TNS2_S120 →	+0.487	+0.062	<.001	<.001	3	7
CCRCC	CACNB2_S460 →	+0.528	+0.119	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086027 vs TNS2 — CCRCC

Explore this scatter interactively →