AV node cell to bundle of His cell signaling

Across TCGA patient cohorts, RNA activity of the AV node cell to bundle of His cell signaling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT10, TRAV6, and ZNF285, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AV node cell to bundle of His cell signaling activity versus KRT10 in OV (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KRT10 →	-0.461	-0.632	.006	.004	3	3
OV	TRAV6 →	-0.662	-0.658	<.001	<.001	3	3
COAD	ZNF285 →	-0.420	-0.616	.009	.001	3	3
GBM	LGI3 →	+1.441	+0.589	<.001	.001	3	3
UCEC	FAR2 →	-0.466	-0.249	.004	.004	3	3
BRCA	SMARCE1P5 →	+0.611	+0.320	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086027 vs KRT10 — OV

Explore this scatter interactively →