AV node cell to bundle of His cell signaling

Across TCGA cell cohorts, RNA activity of the AV node cell to bundle of His cell signaling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G3BP1, EIF5A2, and DYNC2LI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, G3BP1 grouped by AV node cell to bundle of His cell signaling-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	G3BP1 →	+1.177	+2.049	.001	.002	3	5
BONE	EIF5A2 →	+1.312	+1.530	.001	.003	3	4
OVARY	DYNC2LI1 →	-0.796	-1.168	.005	.001	3	4
OVARY	NME9 →	-0.385	-1.385	.008	<.001	3	4
LARGE_INTESTINE	GAB1 →	-1.209	-1.081	.001	<.001	3	4
SOFT_TISSUE	GRPEL2 →	+0.375	+1.042	<.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

G3BP1 by AV node cell to bundle of His cell signaling activity — LIVER

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