Membrane repolarization during cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, TAGLN, and DDR2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during cardiac muscle cell action potential activity versus ACTA2 in CCRCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ACTA2 →	+1.569	+1.124	<.001	<.001	3	7
CCRCC	TAGLN →	+1.798	+1.110	<.001	<.001	3	7
LSCC	DDR2 →	+1.040	+0.539	<.001	<.001	3	7
LSCC	GREM1 →	+1.637	+0.636	<.001	<.001	3	7
CCRCC	MSRB3 →	+0.995	+1.016	<.001	<.001	3	7
LSCC	CALHM5 →	+0.981	+0.761	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086013 vs ACTA2 — CCRCC

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